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LONART / LONART FORTE / LONART DS Tablets is indicated for the treatment of malaria, caused by all forms of Plasmodium including severe malaria caused by multiple drug resistant strains of P. Falciparum.

LONART DS (Artemether 80 mg + Lumefantrine 480 mg)

Orally administered Artemether is rapidly absorbed reaching therapeutic levels within 60-90 minutes Artemether is metabolized in the liver to the demethylated derivate dihydroartemisinin (DHA) The elimination is rapid, with a T1/2 of 2-4 hours Dihydroartemisinin, being a potent antimalarial itself, has a T1/2 of about 2-4 hours.
The degree of binding to plasma proteins varied markedly according to the species studied The binding of Artemether with plasma protein in man is about 50%. Radioactivity distribution of Artemether was found to be equal between celts and plasma.
The absorption of Lumefantrine is highly influenced by lipids and food intake (from 10% by fasten to 100% at normal diet) Therefore parents should be encouraged to give the medication with some fatty food as soon as it can be tolerated.
Lumeiantrine is N-debutylated in human liver microsomes. This metabolite has 5 to 8 fold higher antiparasitic effects than lumefantrine. Lumefantnne is found to be highly protein Pound (95%).
The elimination half life in malaria attaint patients will be 4 to 6 days. Lumefantrine and his metabolities are found in bile and faeces.


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